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Proteomics - Unbiased Study of Proteins and Their Modifications

The myofilament is regulated by protein phosphorylation and other post-translational modifications (PTMs). While antibody-based approaches are useful (and utilized in our lab), they come with a variety of drawbacks including a bias - they can only discover changes that have been looked for. Mass spectrometry provides an un-biased snapshot at a huge number of proteins and PTMs in a sample. Combined with sample fractionation and enrichment, this allows us to observe even very rare events that can have very significant affects in the heart.